Meta-and Pooled Analysis of GSTP1 Polymorphism and Lung Cancer : A HuGE-GSEC Review
Identifieur interne : 008220 ( Main/Exploration ); précédent : 008219; suivant : 008221Meta-and Pooled Analysis of GSTP1 Polymorphism and Lung Cancer : A HuGE-GSEC Review
Auteurs : Michele L. Cote [États-Unis] ; WEI CHEN [États-Unis] ; Daryn W. Smith [États-Unis] ; Simone Benhamou [France] ; Christine Bouchardy [Suisse] ; Dorota Butkiewicz [Pologne] ; Kwun M. Fong [Australie] ; Manuel Gene [Espagne] ; Ari Hirvonen [Finlande] ; Chikako Kiyohara [Japon] ; Jill E. Larsen [États-Unis] ; PINPIN LIN ; Ole Raaschou-Nielsen ; Andrew C. Povey ; Edyta Reszka ; Angela Risch ; Joachim Schneider ; Ann G. Schwartz [États-Unis] ; Mette Sorensen ; Jordi To-Figueras ; Shinkan Tokudome ; YUEPU PU ; PING YANG ; Angela S. Wenzlaff [États-Unis] ; Harriet Wikman ; Emanuela TaioliSource :
- American journal of epidemiology [ 0002-9262 ] ; 2009.
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English descriptors
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Abstract
Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (lle105Val, 313A →313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio = 1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the lle/ Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.
Affiliations:
- Australie, Espagne, Finlande, France, Japon, Pologne, Suisse, États-Unis
- Catalogne, Michigan, Texas, Île-de-France
- Barcelone, Paris
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Meta-and Pooled Analysis of GSTP1 Polymorphism and Lung Cancer : A HuGE-GSEC Review</title><author><name sortKey="Cote, Michele L" sort="Cote, Michele L" uniqKey="Cote M" first="Michele L." last="Cote">Michele L. Cote</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Population Studies and Prevention, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Biostatistics Core, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Smith, Daryn W" sort="Smith, Daryn W" uniqKey="Smith D" first="Daryn W." last="Smith">Daryn W. Smith</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Barbara Ann Karmanos Cancer Institute</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Benhamou, Simone" sort="Benhamou, Simone" uniqKey="Benhamou S" first="Simone" last="Benhamou">Simone Benhamou</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Unit of Cancer Epidemiology (INSERM U351)</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>CNRS FRE2939, Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Bouchardy, Christine" sort="Bouchardy, Christine" uniqKey="Bouchardy C" first="Christine" last="Bouchardy">Christine Bouchardy</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Cancer Registry</s1><s2>Geneva</s2><s3>CHE</s3><sZ>5 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Cancer Registry</wicri:noRegion></affiliation></author><author><name sortKey="Butkiewicz, Dorota" sort="Butkiewicz, Dorota" uniqKey="Butkiewicz D" first="Dorota" last="Butkiewicz">Dorota Butkiewicz</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Tumor Biology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology</s1><s2>Gliwice</s2><s3>POL</s3><sZ>6 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Gliwice</wicri:noRegion></affiliation></author><author><name sortKey="Fong, Kwun M" sort="Fong, Kwun M" uniqKey="Fong K" first="Kwun M." last="Fong">Kwun M. Fong</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Thoracic Medicine, The Prince Charles Hospital</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Gene, Manuel" sort="Gene, Manuel" uniqKey="Gene M" first="Manuel" last="Gene">Manuel Gene</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Public Health Department, University of Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hirvonen, Ari" sort="Hirvonen, Ari" uniqKey="Hirvonen A" first="Ari" last="Hirvonen">Ari Hirvonen</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Finnish Institute of Occupational Health</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>9 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Finnish Institute of Occupational Health</wicri:noRegion></affiliation></author><author><name sortKey="Kiyohara, Chikako" sort="Kiyohara, Chikako" uniqKey="Kiyohara C" first="Chikako" last="Kiyohara">Chikako Kiyohara</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences</s1><s2>Fukuoka</s2><s3>JPN</s3><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, Jill E" sort="Larsen, Jill E" uniqKey="Larsen J" first="Jill E." last="Larsen">Jill E. Larsen</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center</s1><s2>Dallas, Texas</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Pinpin Lin" sort="Pinpin Lin" uniqKey="Pinpin Lin" last="Pinpin Lin">PINPIN LIN</name></author><author><name sortKey="Raaschou Nielsen, Ole" sort="Raaschou Nielsen, Ole" uniqKey="Raaschou Nielsen O" first="Ole" last="Raaschou-Nielsen">Ole Raaschou-Nielsen</name></author><author><name sortKey="Povey, Andrew C" sort="Povey, Andrew C" uniqKey="Povey A" first="Andrew C." last="Povey">Andrew C. Povey</name></author><author><name sortKey="Reszka, Edyta" sort="Reszka, Edyta" uniqKey="Reszka E" first="Edyta" last="Reszka">Edyta Reszka</name></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name></author><author><name sortKey="Schneider, Joachim" sort="Schneider, Joachim" uniqKey="Schneider J" first="Joachim" last="Schneider">Joachim Schneider</name></author><author><name sortKey="Schwartz, Ann G" sort="Schwartz, Ann G" uniqKey="Schwartz A" first="Ann G." last="Schwartz">Ann G. Schwartz</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Population Studies and Prevention, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Sorensen, Mette" sort="Sorensen, Mette" uniqKey="Sorensen M" first="Mette" last="Sorensen">Mette Sorensen</name></author><author><name sortKey="To Figueras, Jordi" sort="To Figueras, Jordi" uniqKey="To Figueras J" first="Jordi" last="To-Figueras">Jordi To-Figueras</name></author><author><name sortKey="Tokudome, Shinkan" sort="Tokudome, Shinkan" uniqKey="Tokudome S" first="Shinkan" last="Tokudome">Shinkan Tokudome</name></author><author><name sortKey="Yuepu Pu" sort="Yuepu Pu" uniqKey="Yuepu Pu" last="Yuepu Pu">YUEPU PU</name></author><author><name sortKey="Ping Yang" sort="Ping Yang" uniqKey="Ping Yang" last="Ping Yang">PING YANG</name></author><author><name sortKey="Wenzlaff, Angela S" sort="Wenzlaff, Angela S" uniqKey="Wenzlaff A" first="Angela S." last="Wenzlaff">Angela S. Wenzlaff</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Population Studies and Prevention, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Wikman, Harriet" sort="Wikman, Harriet" uniqKey="Wikman H" first="Harriet" last="Wikman">Harriet Wikman</name></author><author><name sortKey="Taioli, Emanuela" sort="Taioli, Emanuela" uniqKey="Taioli E" first="Emanuela" last="Taioli">Emanuela Taioli</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0240222</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0240222 INIST</idno><idno type="RBID">Pascal:09-0240222</idno><idno type="wicri:Area/PascalFrancis/Corpus">002D89</idno><idno type="wicri:Area/PascalFrancis/Curation">003231</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002A03</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002A03</idno><idno type="wicri:doubleKey">0002-9262:2009:Cote M:meta:and:pooled</idno><idno type="wicri:Area/Main/Merge">008972</idno><idno type="wicri:Area/Main/Curation">008220</idno><idno type="wicri:Area/Main/Exploration">008220</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Meta-and Pooled Analysis of GSTP1 Polymorphism and Lung Cancer : A HuGE-GSEC Review</title><author><name sortKey="Cote, Michele L" sort="Cote, Michele L" uniqKey="Cote M" first="Michele L." last="Cote">Michele L. Cote</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Population Studies and Prevention, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Biostatistics Core, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Smith, Daryn W" sort="Smith, Daryn W" uniqKey="Smith D" first="Daryn W." last="Smith">Daryn W. Smith</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Barbara Ann Karmanos Cancer Institute</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Benhamou, Simone" sort="Benhamou, Simone" uniqKey="Benhamou S" first="Simone" last="Benhamou">Simone Benhamou</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Unit of Cancer Epidemiology (INSERM U351)</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>CNRS FRE2939, Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Bouchardy, Christine" sort="Bouchardy, Christine" uniqKey="Bouchardy C" first="Christine" last="Bouchardy">Christine Bouchardy</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Cancer Registry</s1><s2>Geneva</s2><s3>CHE</s3><sZ>5 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Cancer Registry</wicri:noRegion></affiliation></author><author><name sortKey="Butkiewicz, Dorota" sort="Butkiewicz, Dorota" uniqKey="Butkiewicz D" first="Dorota" last="Butkiewicz">Dorota Butkiewicz</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Tumor Biology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology</s1><s2>Gliwice</s2><s3>POL</s3><sZ>6 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Gliwice</wicri:noRegion></affiliation></author><author><name sortKey="Fong, Kwun M" sort="Fong, Kwun M" uniqKey="Fong K" first="Kwun M." last="Fong">Kwun M. Fong</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Thoracic Medicine, The Prince Charles Hospital</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Gene, Manuel" sort="Gene, Manuel" uniqKey="Gene M" first="Manuel" last="Gene">Manuel Gene</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Public Health Department, University of Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hirvonen, Ari" sort="Hirvonen, Ari" uniqKey="Hirvonen A" first="Ari" last="Hirvonen">Ari Hirvonen</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Finnish Institute of Occupational Health</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>9 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Finnish Institute of Occupational Health</wicri:noRegion></affiliation></author><author><name sortKey="Kiyohara, Chikako" sort="Kiyohara, Chikako" uniqKey="Kiyohara C" first="Chikako" last="Kiyohara">Chikako Kiyohara</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences</s1><s2>Fukuoka</s2><s3>JPN</s3><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, Jill E" sort="Larsen, Jill E" uniqKey="Larsen J" first="Jill E." last="Larsen">Jill E. Larsen</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center</s1><s2>Dallas, Texas</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Pinpin Lin" sort="Pinpin Lin" uniqKey="Pinpin Lin" last="Pinpin Lin">PINPIN LIN</name></author><author><name sortKey="Raaschou Nielsen, Ole" sort="Raaschou Nielsen, Ole" uniqKey="Raaschou Nielsen O" first="Ole" last="Raaschou-Nielsen">Ole Raaschou-Nielsen</name></author><author><name sortKey="Povey, Andrew C" sort="Povey, Andrew C" uniqKey="Povey A" first="Andrew C." last="Povey">Andrew C. Povey</name></author><author><name sortKey="Reszka, Edyta" sort="Reszka, Edyta" uniqKey="Reszka E" first="Edyta" last="Reszka">Edyta Reszka</name></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name></author><author><name sortKey="Schneider, Joachim" sort="Schneider, Joachim" uniqKey="Schneider J" first="Joachim" last="Schneider">Joachim Schneider</name></author><author><name sortKey="Schwartz, Ann G" sort="Schwartz, Ann G" uniqKey="Schwartz A" first="Ann G." last="Schwartz">Ann G. Schwartz</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Population Studies and Prevention, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Sorensen, Mette" sort="Sorensen, Mette" uniqKey="Sorensen M" first="Mette" last="Sorensen">Mette Sorensen</name></author><author><name sortKey="To Figueras, Jordi" sort="To Figueras, Jordi" uniqKey="To Figueras J" first="Jordi" last="To-Figueras">Jordi To-Figueras</name></author><author><name sortKey="Tokudome, Shinkan" sort="Tokudome, Shinkan" uniqKey="Tokudome S" first="Shinkan" last="Tokudome">Shinkan Tokudome</name></author><author><name sortKey="Yuepu Pu" sort="Yuepu Pu" uniqKey="Yuepu Pu" last="Yuepu Pu">YUEPU PU</name></author><author><name sortKey="Ping Yang" sort="Ping Yang" uniqKey="Ping Yang" last="Ping Yang">PING YANG</name></author><author><name sortKey="Wenzlaff, Angela S" sort="Wenzlaff, Angela S" uniqKey="Wenzlaff A" first="Angela S." last="Wenzlaff">Angela S. Wenzlaff</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Population Studies and Prevention, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Wikman, Harriet" sort="Wikman, Harriet" uniqKey="Wikman H" first="Harriet" last="Wikman">Harriet Wikman</name></author><author><name sortKey="Taioli, Emanuela" sort="Taioli, Emanuela" uniqKey="Taioli E" first="Emanuela" last="Taioli">Emanuela Taioli</name></author></analytic><series><title level="j" type="main">American journal of epidemiology</title><title level="j" type="abbreviated">Am. j. epidemiol.</title><idno type="ISSN">0002-9262</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of epidemiology</title><title level="j" type="abbreviated">Am. j. epidemiol.</title><idno type="ISSN">0002-9262</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bibliographic review</term><term>Epidemiology</term><term>Evidence-based medicine</term><term>Genetics</term><term>Glutathione transferase</term><term>Human</term><term>Iron</term><term>Lung cancer</term><term>Metaanalysis</term><term>Polymorphism</term><term>Public health</term><term>Review</term><term>Tobacco</term><term>Tobacco smoking</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Métaanalyse</term><term>Médecine factuelle</term><term>Cancer du poumon</term><term>Génétique</term><term>Tabagisme</term><term>Homme</term><term>Polymorphisme</term><term>Revue bibliographique</term><term>Article synthèse</term><term>Epidémiologie</term><term>Santé publique</term><term>Glutathione transferase</term><term>Tabac</term><term>Fer</term><term>Gène GSTP1</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Tabagisme</term><term>Homme</term><term>Santé publique</term><term>Tabac</term><term>Fer</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (lle105Val, 313A →313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio = 1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the lle/ Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Japon</li><li>Pologne</li><li>Suisse</li><li>États-Unis</li></country><region><li>Catalogne</li><li>Michigan</li><li>Texas</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Ping Yang" sort="Ping Yang" uniqKey="Ping Yang" last="Ping Yang">PING YANG</name><name sortKey="Pinpin Lin" sort="Pinpin Lin" uniqKey="Pinpin Lin" last="Pinpin Lin">PINPIN LIN</name><name sortKey="Povey, Andrew C" sort="Povey, Andrew C" uniqKey="Povey A" first="Andrew C." last="Povey">Andrew C. Povey</name><name sortKey="Raaschou Nielsen, Ole" sort="Raaschou Nielsen, Ole" uniqKey="Raaschou Nielsen O" first="Ole" last="Raaschou-Nielsen">Ole Raaschou-Nielsen</name><name sortKey="Reszka, Edyta" sort="Reszka, Edyta" uniqKey="Reszka E" first="Edyta" last="Reszka">Edyta Reszka</name><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><name sortKey="Schneider, Joachim" sort="Schneider, Joachim" uniqKey="Schneider J" first="Joachim" last="Schneider">Joachim Schneider</name><name sortKey="Sorensen, Mette" sort="Sorensen, Mette" uniqKey="Sorensen M" first="Mette" last="Sorensen">Mette Sorensen</name><name sortKey="Taioli, Emanuela" sort="Taioli, Emanuela" uniqKey="Taioli E" first="Emanuela" last="Taioli">Emanuela Taioli</name><name sortKey="To Figueras, Jordi" sort="To Figueras, Jordi" uniqKey="To Figueras J" first="Jordi" last="To-Figueras">Jordi To-Figueras</name><name sortKey="Tokudome, Shinkan" sort="Tokudome, Shinkan" uniqKey="Tokudome S" first="Shinkan" last="Tokudome">Shinkan Tokudome</name><name sortKey="Wikman, Harriet" sort="Wikman, Harriet" uniqKey="Wikman H" first="Harriet" last="Wikman">Harriet Wikman</name><name sortKey="Yuepu Pu" sort="Yuepu Pu" uniqKey="Yuepu Pu" last="Yuepu Pu">YUEPU PU</name></noCountry><country name="États-Unis"><region name="Michigan"><name sortKey="Cote, Michele L" sort="Cote, Michele L" uniqKey="Cote M" first="Michele L." last="Cote">Michele L. Cote</name></region><name sortKey="Larsen, Jill E" sort="Larsen, Jill E" uniqKey="Larsen J" first="Jill E." last="Larsen">Jill E. Larsen</name><name sortKey="Schwartz, Ann G" sort="Schwartz, Ann G" uniqKey="Schwartz A" first="Ann G." last="Schwartz">Ann G. Schwartz</name><name sortKey="Smith, Daryn W" sort="Smith, Daryn W" uniqKey="Smith D" first="Daryn W." last="Smith">Daryn W. Smith</name><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name><name sortKey="Wenzlaff, Angela S" sort="Wenzlaff, Angela S" uniqKey="Wenzlaff A" first="Angela S." last="Wenzlaff">Angela S. Wenzlaff</name></country><country name="France"><region name="Île-de-France"><name sortKey="Benhamou, Simone" sort="Benhamou, Simone" uniqKey="Benhamou S" first="Simone" last="Benhamou">Simone Benhamou</name></region><name sortKey="Benhamou, Simone" sort="Benhamou, Simone" uniqKey="Benhamou S" first="Simone" last="Benhamou">Simone Benhamou</name></country><country name="Suisse"><noRegion><name sortKey="Bouchardy, Christine" sort="Bouchardy, Christine" uniqKey="Bouchardy C" first="Christine" last="Bouchardy">Christine Bouchardy</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Butkiewicz, Dorota" sort="Butkiewicz, Dorota" uniqKey="Butkiewicz D" first="Dorota" last="Butkiewicz">Dorota Butkiewicz</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Fong, Kwun M" sort="Fong, Kwun M" uniqKey="Fong K" first="Kwun M." last="Fong">Kwun M. Fong</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Gene, Manuel" sort="Gene, Manuel" uniqKey="Gene M" first="Manuel" last="Gene">Manuel Gene</name></region></country><country name="Finlande"><noRegion><name sortKey="Hirvonen, Ari" sort="Hirvonen, Ari" uniqKey="Hirvonen A" first="Ari" last="Hirvonen">Ari Hirvonen</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Kiyohara, Chikako" sort="Kiyohara, Chikako" uniqKey="Kiyohara C" first="Chikako" last="Kiyohara">Chikako Kiyohara</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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